Bile salt hydrolases: Structure and function, substrate preference, and inhibitor development
نویسندگان
چکیده
منابع مشابه
Genes encoding bile salt hydrolases and conjugated bile salt transporters in Lactobacillus johnsonii 100-100 and other Lactobacillus species.
Lactobacillus johnsonii strain 100-100 expresses two antigenically distinct conjugated bile salt hydrolases (BSH), alpha and beta, that combine to form native homo- and heterotrimers. This paper reports characterization of loci within the genome that encode this capacity. A locus that encodes BSH beta (cbsH beta), a partial (cbsT1) and a complete conjugated bile salt transporter (cbsT2) was ide...
متن کاملBile salt independent retinyl ester hydrolases in the bovine eye.
Homogenates of bovine neuroretina and retinal pigment epithelium (RPE) were incubated with 11-cis and all-trans retinyl palmitate to study retinyl ester hydrolysis. The highest activity was found in RPE when 11-cis retinyl palmitate served as substrate (Km = 7.8 microM and Vmax = 44.8 pmol/min/mg). This retinyl ester hydrolase (REH) had an optimum activity at acidic pH (pH 5), which is in contr...
متن کاملcompactifications and function spaces on weighted semigruops
chapter one is devoted to a moderate discussion on preliminaries, according to our requirements. chapter two which is based on our work in (24) is devoted introducting weighted semigroups (s, w), and studying some famous function spaces on them, especially the relations between go (s, w) and other function speces are invesigated. in fact this chapter is a complement to (32). one of the main fea...
15 صفحه اولStructure-Function Studies of Epoxide Hydrolases
Epoxides are three-membered cyclic ethers formed in cells via several metabolic pathways. Epoxide hydrolases (EHs) are enzymes that hydrolyse epoxides to the corresponding diols. The main goal of this thesis was to investigate the structures of EHs from the / -hydrolase family. The first part concerns the structural and functional analysis of a protein-water channel found in EHs in many plants....
متن کاملBile salt transporters: molecular characterization, function, and regulation.
Molecular medicine has led to rapid advances in the characterization of hepatobiliary transport systems that determine the uptake and excretion of bile salts and other biliary constituents in the liver and extrahepatic tissues. The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSE...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Science
سال: 2018
ISSN: 0961-8368
DOI: 10.1002/pro.3484